Application and characterization of high efficiency wet granulator

High efficiency wet granulating machine in solid preparation is often suitable for the need to add adhesive (such as alcohol, dextrin, etc.) to mix in order to granulate drugs. Wet granulator is used to develop the wet powder into the required particles, but also can destroy the block of dry material to the required particles. In the wet granulation equipment, the horizontal high - speed mixing granulator is the main. The principle of granulation of horizontal high-speed mixing granulator is that mixing and granulation two processes are completed in the same container, the selection of downspin mixing, mixing pulp device in the bottom of the pot, and with the pot bottom to form a gap. Mixing blade surface can ensure that the material bump and slack into a semi-active tumbling condition, and reach sufficient mixing. With the injection of adhesive, the powder is gradually wet, and the shape of the material changes. The swirling motion of the shredding knife and mixing pulp located on the horizontal axis of the pan wall generates eddy currents, so that the materials are mixed, flipped and knocked. At this moment, the shredding knife in the necessary area of material flipping can break the clumps of materials into particles. At the same time, the extrusion, bump, friction, shearing and kneading between particles in the three-dimensional movement of the material make the particle friction more uniform and detailed, eventually forming stable spherical particles and then forming wet uniform soft material. In the meantime, the size of granular mesh is restricted by the characteristics of the material, the speed of the material cutter and the granulation time.

The main feature of high efficiency wet granulator is that the screen is easy to install and disassemble, and can also be properly adjusted. The operation time of each batch of horizontal high efficiency wet granulator is less than 10min, can produce 80~200kg, and the efficiency is 4-5 times better than the traditional process. The seven-angle drum is convenient to disassemble and simple to clean. The mechanical transmission system is all closed in the body, and with a smooth system, the whole machine runs smoothly. The body is an independent cuboid, which is composed of bearing frame, reducer box and frame. The charging powder bucket connects with the bearing frame and extends to the outside of the machine. The front end of the frame is planned to extend out, land widely and smoothly, so it does not need to be installed and can be arbitrarily placed for indoor use. Particle production device: rotating drum horizontal device under the hopper, before and after the bearing support, it through the rack drive, for reverse rotation. The front bearing seat of the end face is movable. When assembling and disassembling, only three screws need to be unscrewed, and the front bearing seat and rotating drum can be extracted in sequence. The two ends of the rotating drum are symmetrical convex joint, which is not subject to the reverse constraint and convenient for installation and disassembly.